| 任新,赵雪松,段小月,刘萍,贾晨梦,庞蒙蒙.四溴二苯醚与高氯酸盐联合暴露对成年斑马鱼肝脏抗氧化系统的影响[J].唐山学院学报,2018,31(3):29-34 |
| 四溴二苯醚与高氯酸盐联合暴露对成年斑马鱼肝脏抗氧化系统的影响 |
| Effects of Combined Exposure of Tetrabromodiphenyl Ether and Perchlorate on Antioxidant System in Adult Zebrafish Liver |
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| DOI：10.16160/j.cnki.tsxyxb.2018.03.007 |
| 中文关键词: 四溴二苯醚 高氯酸盐 联合暴露 成年斑马鱼 抗氧化系统 |
| 英文关键词: tetrabromodiphenyl ether perchlorate combined exposure adult zebrafish antioxidant system |
| 基金项目:国家自然科学基金项目（21507039）；吉林省科技厅青年科研基金项目（20170520072JH） |
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| 中文摘要: |
| 实验选择四溴二苯醚（BDE-47）与高氯酸盐（PER）作为研究对象，系统研究了二者联合暴露对成年斑马鱼肝脏抗氧化系统的影响。实验设置（BDE-47 8.5+PER 335） mg/L，（BDE-47 0.85+PER 33.5） mg/L，（BDE-47 0.085+PER 3.35） mg/L三种联合暴露组及二者各自单一的暴露组。暴露14天后，分别测定雌雄斑马鱼肝脏内超氧化物歧化酶（SOD）活性、过氧化氢酶（CAT）活性、谷胱甘肽过氧化物酶（Gpx）活性以及脂质过氧化物（MDA）水平。结果显示，与两种物质单一暴露相比，联合暴露致使肝脏内SOD，CAT的活性增加，MDA水平增加，而GSH活性降低，实验说明，PER诱导加剧了BDE-47对成年斑马鱼肝脏抗氧化酶的影响，进一步产生了氧化应激。 |
| 英文摘要: |
| The effects of combined exposure of tetrabromodiphenyl ether and perchlorate on the antioxidant system in adult zebrafish liver were studied systematically. In the experiment, the combinations of the two substances were set at (tetrabromodiphenyl ether 8.5+ perchlorate 335) mg/L, (tetrabromodiphenyl ether 0.85+ perchlorate 33.5) mg/L, (tetrabromodiphenyl ether 0.085+ perchlorate 3.35) mg/L, and the zebrafish were exposed to the three combinations respectively, and to each of the two substances. 14 days after the exposure, the activity of superoxide dismutase, catalase, glutathione peroxidase and lipid peroxide in the liver of male and male zebra fish were measured. The results show that compared with the single exposure of the two substances, the activity of superoxide dismutase, catalase increases in the liver, the lipid peroxide level also increases, and the activity of GSH decreases, under the exposure of tetrabromodiphenyl ether and perchlorate. The experiment also indicats that perchlorate aggravates the effect of tetrabromodiphenyl ether on the antioxidant enzymes in the liver of adult zebrafish, thus producing the oxidative stress. |
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